Two serines in the distal C-terminus of the human ß(1)-adrenoceptor determine ß-arrestin2 recruitment

G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment and receptor desensitization. The exact sites of phosphorylation and their function remained largel...

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Publicat a:PLoS One
Autors principals: Hinz, Laura, Ahles, Andrea, Ruprecht, Benjamin, Küster, Bernhard, Engelhardt, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417508/
https://ncbi.nlm.nih.gov/pubmed/28472170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176450
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