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Interhelical Interaction and Receptor Phosphorylation Regulate the Activation Kinetics of Different Human β(1)-Adrenoceptor Variants
G protein-coupled receptors represent the largest class of drug targets, but genetic variation within G protein-coupled receptors leads to variable drug responses and, thereby, compromises their therapeutic application. One of the most intensely studied examples is a hyperfunctional variant of the h...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340418/ https://ncbi.nlm.nih.gov/pubmed/25451930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607333 |
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