Real-time optical recording of β(1)-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

Antagonists of β-adrenergic receptors (β-ARs) have become a main therapeutic regimen for the treatment of heart failure even though the mechanisms of their beneficial effects are still poorly understood. Here, we used fluorescent resonance energy transfer–based (FRET-based) approaches to directly mo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Rochais, Francesca, Vilardaga, Jean-Pierre, Nikolaev, Viacheslav O., Bünemann, Moritz, Lohse, Martin J., Engelhardt, Stefan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2007
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751291/
https://ncbi.nlm.nih.gov/pubmed/17200720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30012
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