Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

BACKGROUND: During liver injury, hepatic stellate cells (HSCs) can undergo activation and transform into alpha-smooth muscle actin (αSMA)-expressing contractile myofibroblast-like cells, leading to deposition of excessive scar matrix. We have recently demonstrated that depletion of adenosine deamina...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kagan, Polina, Sultan, Maya, Tachlytski, Irina, Safran, Michal, Ben-Ari, Ziv
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417441/
https://ncbi.nlm.nih.gov/pubmed/28472150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176173
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