Regulation of Adipocyte Differentiation by Activation of Serotonin (5-HT) Receptors 5-HT(2A)R and 5-HT(2C)R and Involvement of MicroRNA-448-Mediated Repression of KLF5

Retrovirus insertion-mediated random mutagenesis was applied in 3T3-L1 preadipocyte cells to better understand the molecular basis of obesity (the expansion of individual adipocytes). We found that tryptophan hydroxylase-1, a rate-limiting enzyme for the synthesis of serotonin (5-HT), is expressed i...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Endocrinol
Hauptverfasser: Kinoshita, Minako, Ono, Koh, Horie, Takahiro, Nagao, Kazuya, Nishi, Hitoo, Kuwabara, Yasuhide, Takanabe-Mori, Rieko, Hasegawa, Koji, Kita, Toru, Kimura, Takeshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2010
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417392/
https://ncbi.nlm.nih.gov/pubmed/20719859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0054
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