Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice

BACKGROUND: The mechanism of cardiac energy production against sustained pressure overload remains to be elucidated. METHODS AND RESULTS: We generated cardiac-specific kinase-dead (kd) calcium/calmodulin-dependent protein kinase kinase-β (CaMKKβ) transgenic (α-MHC CaMKKβ(kd) TG) mice using α-myosin...

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Detalhes bibliográficos
Main Authors: Watanabe, Shin, Horie, Takahiro, Nagao, Kazuya, Kuwabara, Yasuhide, Baba, Osamu, Nishi, Hitoo, Sowa, Naoya, Narazaki, Michiko, Matsuda, Tetsuya, Takemura, Genzou, Wada, Hiromichi, Hasegawa, Koji, Kimura, Takeshi, Ono, Koh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177887/
https://ncbi.nlm.nih.gov/pubmed/25255457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108201
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