Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway

AIMS: A significant increase in congestive heart failure (CHF) was reported when the anti-ErbB2 antibody trastuzumab was used in combination with the chemotherapy drug doxorubicin (Dox). The aim of the present study was to investigate the role(s) of miRNAs in acute Dox-induced cardiotoxicity. METHOD...

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Autors principals: Horie, Takahiro, Ono, Koh, Nishi, Hitoo, Nagao, Kazuya, Kinoshita, Minako, Watanabe, Shin, Kuwabara, Yasuhide, Nakashima, Yasuhiro, Takanabe-Mori, Rieko, Nishi, Eiichiro, Hasegawa, Koji, Kita, Toru, Kimura, Takeshi
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920811/
https://ncbi.nlm.nih.gov/pubmed/20495188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq148
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