Calcium Signaling Regulates Trafficking of Familial Hypocalciuric Hypercalcemia (FHH) Mutants of the Calcium Sensing Receptor

Calcium-sensing receptors (CaSRs) regulate systemic Ca(2+) homeostasis. Loss-of-function mutations cause familial benign hypocalciuric hypercalcemia (FHH) or neonatal severe hyperparathyroidism (NSHPT). FHH/NSHPT mutations can reduce trafficking of CaSRs to the plasma membrane. CaSR signaling is pot...

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Bibliografiske detaljer
Udgivet i:Mol Endocrinol
Main Authors: Grant, Michael P., Stepanchick, Ann, Breitwieser, Gerda E.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2012
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416950/
https://ncbi.nlm.nih.gov/pubmed/23077345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1232
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