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Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists
Mutations in MSX1 cause craniofacial developmental defects, including tooth agenesis, in humans and mice. Previous studies suggest that Msx1 activates Bmp4 expression in the developing tooth mesenchyme to drive early tooth organogenesis. Whereas Msx1(−/−) mice exhibit developmental arrest of all too...
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| Veröffentlicht in: | Dev Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5416936/ https://ncbi.nlm.nih.gov/pubmed/27713059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2016.10.001 |
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