Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood

Non–transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and...

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Опубликовано в: :JCI Insight
Главные авторы: Baek, Jin Hyen, Yalamanoglu, Ayla, Gao, Yamei, Guenster, Ricardo, Spahn, Donat R., Schaer, Dominik J., Buehler, Paul W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414558/
https://ncbi.nlm.nih.gov/pubmed/28469086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93577
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