Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood

Non–transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Baek, Jin Hyen, Yalamanoglu, Ayla, Gao, Yamei, Guenster, Ricardo, Spahn, Donat R., Schaer, Dominik J., Buehler, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414558/
https://ncbi.nlm.nih.gov/pubmed/28469086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93577
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