MicroRNA-29 overexpression by adeno-associated virus suppresses fibrosis and restores muscle function in combination with micro-dystrophin

Duchenne muscular dystrophy (DMD) is caused by dystrophin deficiency resulting in progressive muscle weakness and fibrotic scarring. Muscle fibrosis impairs blood flow, hampering muscle repair and regeneration. Irrespective of the success of gene restoration, functional improvement is limited withou...

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Publicat a:JCI Insight
Autors principals: Heller, Kristin N., Mendell, Joshua T., Mendell, Jerry R., Rodino-Klapac, Louise R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414552/
https://ncbi.nlm.nih.gov/pubmed/28469083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93309
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