Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene. It is the most common, severe childhood form of muscular dystrophy. We investigated an alternative to dystrophin replacement by overexpressing ITGA7 using adeno-associated virus (AAV) delivery. ITGA7 is a laminin receptor in s...

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Bibliografiske detaljer
Udgivet i:Hum Gene Ther
Main Authors: Heller, Kristin N., Montgomery, Chrystal L., Shontz, Kimberly M., Clark, K. Reed, Mendell, Jerry R., Rodino-Klapac, Louise R.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630797/
https://ncbi.nlm.nih.gov/pubmed/26076707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.062
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