Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene. It is the most common, severe childhood form of muscular dystrophy. We investigated an alternative to dystrophin replacement by overexpressing ITGA7 using adeno-associated virus (AAV) delivery. ITGA7 is a laminin receptor in s...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Heller, Kristin N., Montgomery, Chrystal L., Shontz, Kimberly M., Clark, K. Reed, Mendell, Jerry R., Rodino-Klapac, Louise R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630797/
https://ncbi.nlm.nih.gov/pubmed/26076707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.062
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