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Systems-level analysis of mechanisms regulating yeast metabolic flux

Cellular metabolic fluxes are determined by enzyme activities and metabolite abundances. Biochemical approaches reveal the impact of specific substrates or regulators on enzyme kinetics, but do not capture the extent to which metabolite and enzyme concentrations vary across physiological states, and...

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Publicado en:Science
Main Authors: Hackett, Sean R., Zanotelli, Vito R.T., Xu, Wenxin, Goya, Jonathan, Park, Junyoung O., Perlman, David H., Gibney, Patrick A., Botstein, David, Storey, John D., Rabinowitz, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414049/
https://ncbi.nlm.nih.gov/pubmed/27789812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2786
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