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Systems-level analysis of mechanisms regulating yeast metabolic flux

Cellular metabolic fluxes are determined by enzyme activities and metabolite abundances. Biochemical approaches reveal the impact of specific substrates or regulators on enzyme kinetics, but do not capture the extent to which metabolite and enzyme concentrations vary across physiological states, and...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Hackett, Sean R., Zanotelli, Vito R.T., Xu, Wenxin, Goya, Jonathan, Park, Junyoung O., Perlman, David H., Gibney, Patrick A., Botstein, David, Storey, John D., Rabinowitz, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414049/
https://ncbi.nlm.nih.gov/pubmed/27789812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2786
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