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Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding
Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biom...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413348/ https://ncbi.nlm.nih.gov/pubmed/28432788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23990 |
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