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Structure of protein O-mannose kinase reveals a unique active site architecture
The ‘pseudokinase’ SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on α-dystroglycan. However, the catalytic mechanism underlying this activity remains elusive. Here we present the crystal structure of Dan...
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| Опубликовано в: : | eLife |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142810/ https://ncbi.nlm.nih.gov/pubmed/27879205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22238 |
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