Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biom...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Cui, Jixin, Zhu, Qinyu, Zhang, Hui, Cianfrocco, Michael A, Leschziner, Andres E, Dixon, Jack E, Xiao, Junyu
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413348/
https://ncbi.nlm.nih.gov/pubmed/28432788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23990
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