POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan

Matriglycan [-GlcA-β1,3-Xyl-α1,3-](n) serves as a scaffold in many tissues for extracellular matrix proteins containing laminin-G domains including laminin, agrin, and perlecan. Like-acetyl-glucosaminyltransferase 1 (LARGE1) synthesizes and extends matriglycan on α-dystroglycan (α-DG) during skeleta...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Walimbe, Ameya S, Okuma, Hidehiko, Joseph, Soumya, Yang, Tiandi, Yonekawa, Takahiro, Hord, Jeffrey M, Venzke, David, Anderson, Mary E, Torelli, Silvia, Manzur, Adnan, Devereaux, Megan, Cuellar, Marco, Prouty, Sally, Ocampo Landa, Saul, Yu, Liping, Xiao, Junyu, Dixon, Jack E, Muntoni, Francesco, Campbell, Kevin P
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556876/
https://ncbi.nlm.nih.gov/pubmed/32975514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61388
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