Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma

BACKGROUND: α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via a unique heteropolysaccharide [-GlcA-beta1,3-Xyl-alpha1,3-](n) called matriglyc...

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Gepubliceerd in:Skelet Muscle
Hoofdauteurs: Beltrán, Daniel, Anderson, Mary E., Bharathy, Narendra, Settelmeyer, Teagan P., Svalina, Matthew N., Bajwa, Zia, Shern, John F., Gultekin, Sakir H., Cuellar, Marco A., Yonekawa, Takahiro, Keller, Charles, Campbell, Kevin P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500046/
https://ncbi.nlm.nih.gov/pubmed/31054580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-019-0195-0
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