POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan

Matriglycan [-GlcA-β1,3-Xyl-α1,3-](n) serves as a scaffold in many tissues for extracellular matrix proteins containing laminin-G domains including laminin, agrin, and perlecan. Like-acetyl-glucosaminyltransferase 1 (LARGE1) synthesizes and extends matriglycan on α-dystroglycan (α-DG) during skeleta...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Walimbe, Ameya S, Okuma, Hidehiko, Joseph, Soumya, Yang, Tiandi, Yonekawa, Takahiro, Hord, Jeffrey M, Venzke, David, Anderson, Mary E, Torelli, Silvia, Manzur, Adnan, Devereaux, Megan, Cuellar, Marco, Prouty, Sally, Ocampo Landa, Saul, Yu, Liping, Xiao, Junyu, Dixon, Jack E, Muntoni, Francesco, Campbell, Kevin P
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556876/
https://ncbi.nlm.nih.gov/pubmed/32975514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61388
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