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Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation
Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor. Using mouse models, we show that hepatocyte-specific deletion of c-Fos protects against diethylnitrosamine (DEN)-induced HCCs, wh...
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Publicado no: | J Exp Med |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Rockefeller University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413325/ https://ncbi.nlm.nih.gov/pubmed/28356389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160935 |
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