Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers

Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. The Fos-related antigen 1 (Fra-1) and 2 (Fra-2) prevent...

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Autori principali: Hasenfuss, Sebastian C., Bakiri, Latifa, Thomsen, Martin K., Williams, Evan G., Auwerx, Johan, Wagner, Erwin F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023468/
https://ncbi.nlm.nih.gov/pubmed/24411941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.018
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