Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation

Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor. Using mouse models, we show that hepatocyte-specific deletion of c-Fos protects against diethylnitrosamine (DEN)-induced HCCs, wh...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Bakiri, Latifa, Hamacher, Rainer, Graña, Osvaldo, Guío-Carrión, Ana, Campos-Olivas, Ramón, Martinez, Lola, Dienes, Hans P., Thomsen, Martin K., Hasenfuss, Sebastian C., Wagner, Erwin F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413325/
https://ncbi.nlm.nih.gov/pubmed/28356389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160935
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