Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

Transforming growth factor-β (TGF-β) plays an important role in the development and maintenance of embryonic dopaminergic (DA) neurons in the midbrain. To study the function of TGF-β signaling in the adult nigrostriatal system, we generated transgenic mice with reduced TGF-β signaling in mature neur...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tesseur, Ina, Nguyen, Andy, Chang, Betty, Li, Lulin, Woodling, Nathaniel S., Wyss-Coray, Tony, Luo, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413189/
https://ncbi.nlm.nih.gov/pubmed/28363982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2952-16.2017
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