A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies

The Neuronal Ceroid Lipofuscinoses (NCLs), also known as Batten disease, result from mutations in over a dozen genes. Although, adults are susceptible, the NCLs are frequently classified as pediatric neurodegenerative diseases due to their greater pediatric prevalence. Initial clinical presentation...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Geraets, Ryan D., Langin, Logan M., Cain, Jacob T., Parker, Camille M., Beraldi, Rosanna, Kovacs, Attila D., Weimer, Jill M., Pearce, David A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413059/
https://ncbi.nlm.nih.gov/pubmed/28464005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176526
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items