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Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function
Mutations of GLI-similar 3 (GLIS3) underlie a neonatal diabetes syndrome. Genome-wide association studies revealed that GLIS3 variants are associated with both common type 1 and type 2 diabetes. Global Glis3-deficient (Glis3(−/−)) mice die of severe diabetes shortly after birth. GLIS3 controls islet...
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| Publicado no: | Endocrinology |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412984/ https://ncbi.nlm.nih.gov/pubmed/27813676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1541 |
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