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Whole‐cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production

Many high‐value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimize the productivity of these cultures it is important to monitor cellular metabolism, for example the utilization of nutrients and the accumulation of metaboli...

詳細記述

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書誌詳細
出版年:Biotechnol Bioeng
主要な著者: Goers, Lisa, Ainsworth, Catherine, Goey, Cher Hui, Kontoravdi, Cleo, Freemont, Paul S., Polizzi, Karen M.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412874/
https://ncbi.nlm.nih.gov/pubmed/28112405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26254
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