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Whole‐cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production

Many high‐value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimize the productivity of these cultures it is important to monitor cellular metabolism, for example the utilization of nutrients and the accumulation of metaboli...

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Bibliografiske detaljer
Udgivet i:Biotechnol Bioeng
Main Authors: Goers, Lisa, Ainsworth, Catherine, Goey, Cher Hui, Kontoravdi, Cleo, Freemont, Paul S., Polizzi, Karen M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412874/
https://ncbi.nlm.nih.gov/pubmed/28112405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26254
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