Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment

Viral quasispecies evolution upon long-term virus replication in a noncoevolving cellular environment raises relevant general issues, such as the attainment of population equilibrium, compliance with the molecular-clock hypothesis, or stability of the phenotypic profile. Here, we evaluate the adapta...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Moreno, Elena, Gallego, Isabel, Gregori, Josep, Lucía-Sanz, Adriana, Soria, María Eugenia, Castro, Victoria, Beach, Nathan M., Manrubia, Susanna, Quer, Josep, Esteban, Juan Ignacio, Rice, Charles M., Gómez, Jordi, Gastaminza, Pablo, Domingo, Esteban, Perales, Celia
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Genome Replication and Regulation of Viral Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411618/
https://ncbi.nlm.nih.gov/pubmed/28275194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02505-16
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