Attenuated Human Parainfluenza Virus Type 1 Expressing Ebola Virus Glycoprotein GP Administered Intranasally Is Immunogenic in African Green Monkeys

The recent 2014-2016 Ebola virus (EBOV) outbreak prompted increased efforts to develop vaccines against EBOV disease. We describe the development and preclinical evaluation of an attenuated recombinant human parainfluenza virus type 1 (rHPIV1) expressing the membrane-anchored form of EBOV glycoprote...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lingemann, Matthias, Liu, Xueqiao, Surman, Sonja, Liang, Bo, Herbert, Richard, Hackenberg, Ashley D., Buchholz, Ursula J., Collins, Peter L., Munir, Shirin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411581/
https://ncbi.nlm.nih.gov/pubmed/28250127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02469-16
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