PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Kory, Nora, Pacold, Michael E., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Sabatini, David M., Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410781/
https://ncbi.nlm.nih.gov/pubmed/28396387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617922114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados