Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Status epilepticus (SE), a medical emergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfunction typified by neurodegeneration, inflammation, altered neurogenesis, as well as cognitive and memory deficits. Here, we examined the effects of intranasal (I...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Long, Qianfa, Upadhya, Dinesh, Hattiangady, Bharathi, Kim, Dong-Ki, An, Su Yeon, Shuai, Bing, Prockop, Darwin J., Shetty, Ashok K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410779/
https://ncbi.nlm.nih.gov/pubmed/28396435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703920114
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