Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Status epilepticus (SE), a medical emergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfunction typified by neurodegeneration, inflammation, altered neurogenesis, as well as cognitive and memory deficits. Here, we examined the effects of intranasal (I...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Long, Qianfa, Upadhya, Dinesh, Hattiangady, Bharathi, Kim, Dong-Ki, An, Su Yeon, Shuai, Bing, Prockop, Darwin J., Shetty, Ashok K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410779/
https://ncbi.nlm.nih.gov/pubmed/28396435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703920114
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