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Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases

Increasing hepatic stellate cell (HSC) death is a very attractive approach for limiting liver fibrosis. Tyrosine kinase inhibitors have been shown to have anti-fibrotic properties, but the mechanisms are poorly understood. Here, we identified the mechanism of action of the second-generation tyrosine...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Shaker, Mohamed E., Ghani, Ayaz, Shiha, Gamal E., Ibrahim, Tarek M., Mehal, Wajahat Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410771/
https://ncbi.nlm.nih.gov/pubmed/23499874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.02.033
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