dUTPase inhibition augments replication defects of 5-Fluorouracil

The antimetabolite 5-Fluorouracil (5-FU) is used in the treatment of various forms of cancer and has a complex mode of action. Despite 6 decades in clinical application the contribution of 5-FdUTP and dUTP [(5-F)dUTP] and 5-FUTP misincorporation into DNA and RNA respectively, for 5-FU-induced toxici...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Hagenkort, Anna, Paulin, Cynthia B.J., Desroses, Matthieu, Sarno, Antonio, Wiita, Elisée, Mortusewicz, Oliver, Koolmeister, Tobias, Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Homan, Evert, Lundbäck, Thomas, Gustavsson, Anna-Lena, Scobie, Martin, Helleday, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410339/
https://ncbi.nlm.nih.gov/pubmed/28423595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15785
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller