Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome

The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma cells (BMSCs) determines a protective environment that favors tumor development and resistance to conventional chemotherapy. We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Macanas-Pirard, Patricia, Broekhuizen, Richard, González, Alfonso, Oyanadel, Claudia, Ernst, Daniel, García, Patricia, Montecinos, Viviana P., Court, Felipe, Ocqueteau, Mauricio, Ramirez, Pablo, Nervi, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410286/
https://ncbi.nlm.nih.gov/pubmed/28160570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14981
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