The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia

Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia (AML). Aberrant expression of enzymes involved in the transport/metabolism of ara-C could explain drug resistance. We determined mRNA expression of these factors using quantitative-real-time-PCR in leukemic b...

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Detalhes bibliográficos
Main Authors: Hubeek, I, Stam, R W, Peters, G J, Broekhuizen, R, Meijerink, J P P, Wering, E R van, Gibson, B E S, Creutzig, U, Zwaan, C M, Cloos, J, Kuik, D J, Pieters, R, Kaspers, G J L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361532/
https://ncbi.nlm.nih.gov/pubmed/16333246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602881
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