The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) has a high mortality rate despite chemotherapy and transplantation. Both CXCR4/SDF-1 and VLA-4/VCAM1 axes are involved in leukemia protection but little is known about the role of CCL2/CCR2 in AML biology and protection against chemotherapy. We measured CCR2 expression i...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Macanas-Pirard, Patricia, Quezada, Thomas, Navarrete, Leonardo, Broekhuizen, Richard, Leisewitz, Andrea, Nervi, Bruno, Ramírez, Pablo A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207636/
https://ncbi.nlm.nih.gov/pubmed/28045930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168888
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