Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR

PURPOSE: The aim of this work was to investigate the efficacy of sequential treatment with first-, second- and third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and the mechanisms of acquired resistance occurring during the sequential use of these inhibitors. EXPERI...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Della Corte, Carminia Maria, Malapelle, Umberto, Vigliar, Elena, Pepe, Francesco, Troncone, Giancarlo, Ciaramella, Vincenza, Troiani, Teresa, Martinelli, Erika, Belli, Valentina, Ciardiello, Fortunato, Morgillo, Floriana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410282/
https://ncbi.nlm.nih.gov/pubmed/28416737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15479
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