Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS

Strict L-chiral rejection through Gly-cisPro motif during chiral proofreading underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discriminate between D-amino acids and achiral glycine. The consequent Gly-tRNA(Gly) ‘misediting paradox’ is resolved by EF-Tu in the cell. Here, we show that...

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Veröffentlicht in:eLife
Hauptverfasser: Pawar, Komal Ishwar, Suma, Katta, Seenivasan, Ayshwarya, Kuncha, Santosh Kumar, Routh, Satya Brata, Kruparani, Shobha P, Sankaranarayanan, Rajan
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409826/
https://ncbi.nlm.nih.gov/pubmed/28362257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24001
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