Specificity and catalysis hardwired at the RNA–protein interface in a translational proofreading enzyme

Proofreading modules of aminoacyl-tRNA synthetases are responsible for enforcing a high fidelity during translation of the genetic code. They use strategically positioned side chains for specifically targeting incorrect aminoacyl-tRNAs. Here, we show that a unique proofreading module possessing a D-...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ahmad, Sadeem, Muthukumar, Sowndarya, Kuncha, Santosh Kumar, Routh, Satya Brata, Yerabham, Antony S.K., Hussain, Tanweer, Kamarthapu, Venu, Kruparani, Shobha P, Sankaranarayanan, Rajan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491819/
https://ncbi.nlm.nih.gov/pubmed/26113036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8552
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