A discriminator code–based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria

D-aminoacyl-tRNA deacylase (DTD) acts on achiral glycine, in addition to D-amino acids, attached to tRNA. We have recently shown that this activity enables DTD to clear non-cognate Gly-tRNA(Ala) with 1000-fold higher efficiency than its activity on Gly-tRNA(Gly), indicating tRNA-based modulation of...

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Udgivet i:eLife
Main Authors: Kuncha, Santosh Kumar, Suma, Katta, Pawar, Komal Ishwar, Gogoi, Jotin, Routh, Satya Brata, Pottabathini, Sambhavi, Kruparani, Shobha P, Sankaranarayanan, Rajan
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097841/
https://ncbi.nlm.nih.gov/pubmed/30091703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38232
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