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Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance

Inflammatory signals induce feedback and feedforward systems that provide temporal control. Although glucocorticoids can repress inflammatory gene expression, glucocorticoid receptor recruitment increases expression of negative feedback and feedforward regulators, including the phosphatase, DUSP1, t...

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Pubblicato in:J Biol Chem
Autori principali: Newton, Robert, Shah, Suharsh, Altonsy, Mohammed O., Gerber, Antony N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409484/
https://ncbi.nlm.nih.gov/pubmed/28283576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R117.777318
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