Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca(2+)/Mn(2+)-transport ATPase (SPCA1a)

The Golgi/secretory pathway Ca(2+)/Mn(2+)-transport ATPase (SPCA1a) is implicated in breast cancer and Hailey-Hailey disease. Here, we purified recombinant human SPCA1a from Saccharomyces cerevisiae and measured Ca(2+)-dependent ATPase activity following reconstitution in proteoliposomes. The purifi...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Chen, Jialin, De Raeymaecker, Joren, Hovgaard, Jannik Brøndsted, Smaardijk, Susanne, Vandecaetsbeek, Ilse, Wuytack, Frank, Møller, Jesper Vuust, Eggermont, Jan, De Maeyer, Marc, Christensen, Søren Brøgger, Vangheluwe, Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409463/
https://ncbi.nlm.nih.gov/pubmed/28264934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778431
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