α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection

α-Synuclein (aS) is a protein abundant in presynaptic nerve terminals in Parkinson disease (PD) and is a major component of intracellular Lewy bodies, the pathological hallmark of neurodegenerative disorders such as PD. Accordingly, the relationships between aS structure, its interaction with lipids...

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Foilsithe in:J Biol Chem
Main Authors: De Franceschi, Giorgia, Fecchio, Chiara, Sharon, Ronit, Schapira, Anthony H. V., Proukakis, Christos, Bellotti, Vittorio, de Laureto, Patrizia Polverino
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2017
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409462/
https://ncbi.nlm.nih.gov/pubmed/28232489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.765149
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