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Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments

Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution of adaptive conflicts, and 2) non-adaptive processe...

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Vydáno v:PLoS Genet
Hlavní autoři: Nguyen Ba, Alex N., Strome, Bob, Osman, Selma, Legere, Elizabeth-Ann, Zarin, Taraneh, Moses, Alan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409178/
https://ncbi.nlm.nih.gov/pubmed/28410373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006735
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