Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments

Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution of adaptive conflicts, and 2) non-adaptive processe...

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Bibliografische gegevens
Gepubliceerd in:PLoS Genet
Hoofdauteurs: Nguyen Ba, Alex N., Strome, Bob, Osman, Selma, Legere, Elizabeth-Ann, Zarin, Taraneh, Moses, Alan M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409178/
https://ncbi.nlm.nih.gov/pubmed/28410373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006735
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