Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments

Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution of adaptive conflicts, and 2) non-adaptive processe...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Nguyen Ba, Alex N., Strome, Bob, Osman, Selma, Legere, Elizabeth-Ann, Zarin, Taraneh, Moses, Alan M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409178/
https://ncbi.nlm.nih.gov/pubmed/28410373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006735
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