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Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain
HSJ1 (DNAJB2), a member of the DNAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance. It binds ubiquitylated proteins through its Ubiquitin Interacting Motifs (UIMs) and facilitates their delivery to the proteasome for degradation. Mutations in the DNAJB2 gene lea...
में बचाया:
| में प्रकाशित: | Hum Mol Genet |
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| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409130/ https://ncbi.nlm.nih.gov/pubmed/28031292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw420 |
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